Melanocytic lesions of the conjunctiva

This article reviews the clinico-pathological details of common benign and malignant melanocytic lesions of the conjunctiva. Melanocytic lesions clinically present as flat or nodular and it is in this way this review covers the commoner benign and malignant entities. Several types of naevi can be identified in the conjunctiva, with some site-specific peculiarities, familiarisation with which will allow a correct interpretation. Benign and atypical, ‘flat’ intraepithelial melanocytic lesions are covered in detail as they constitute many cases of referred material to specialist ophthalmic pathologists. The various classification schemes for atypical intraepithelial melanocytes are covered. Common histological and prognostic details for invasive melanoma are mentioned. Ambiguous lesions are alluded to and how ancillary molecular investigations help in this regard, along with a brief summary of the recent advancements in the molecular biology for conjunctival melanoma.