Histologic variants of chondrosarcoma

The histologic subtypes of chondrosarcoma are uncommon. Despite their rarity, they present with characteristic clinical and histopathologic features distinguishing them from conventional type of chondrosarcoma. The histologic variants, clear cell and mesenchymal chondrosarcoma, are reviewed herein. Dedifferentiated chondrosarcoma, although typically arising from conventional chondrosarcoma, is also reviewed due to its distinct histomorphology. Finally, so-called extraskeletal myxoid chondrosarcoma, which may rarely arise primary in bone, is also discussed despite its uncertain histogenesis.