Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4132510 | Human Pathology | 2016 | 11 Pages |
Abstract
SummaryGATA3 is a zinc-binding transcription factor that regulates the differentiation of many human tissue types, including the mammary gland. In surgical pathology, immunohistochemistry for GATA3 is largely used to support urothelial or breast origin in a carcinoma of unknown origin. GATA3 is sensitive but not entirely specific in this setting. Although GATA3 labeling is highest in estrogen receptor–positive carcinomas, it also labels estrogen receptor–negative carcinomas and thus has particular diagnostic utility in the setting of triple-negative breast carcinomas, which are typically negative for other mammary-specific markers.
Related Topics
Health Sciences
Medicine and Dentistry
Pathology and Medical Technology
Authors
Rebecca Asch-Kendrick, Ashley Cimino-Mathews,