Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4133141 | Human Pathology | 2012 | 10 Pages |
Abstract
SummaryGastroesophageal reflux disease is associated with impaired epithelial barrier function and abnormal expression of proteins forming cell-cell contacts by tight junctions and desmosomes in distal esophageal squamous mucosa. Although gastroesophageal reflux disease and Helicobacter pylori are both associated with chronic inflammation of the adjacent cardia mucosa, it is not known whether these lead to derangements of the desmosomal complexes. Here, we assessed the expression of 4 proteins (plakoglobin and desmoglein 1, 2, and 3) forming epithelial desmosomal complexes by quantitative reverse transcription polymerase chain reaction and immunohistochemistry in bi
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Authors
Thomas Wex, Doerthe Kuester, Klaus Mönkemüller, Antje Stahr, Lucia C. Fry, Arne Kandulski, Siegfried Kropf, Albert Roessner, Peter Malfertheiner,