| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4133233 | Human Pathology | 2013 | 5 Pages |
Abstract
SummaryChronic myeloid leukemia (CML) is a hematopoietic stem cell disorder that occurs because of t(9;22)(q34;q11) translocations. Complex translocations have been reported in CML. We report a novel 5-way translocation 46,XY,t(9;11;13;19;22)(9q34.12;11p11.12;13q21.31;19q13.12;22q11.21) using GTG banding, fluorescence in situ hybridization, and spectral karyotyping in a case of chronic-phase CML. Molecular analysis revealed the presence of 2 types of transcripts (b3a2, b2a2). The patient was responding to the imatinib treatment. However, the patient needs to be carefully monitored at various intervals.
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Authors
Shantashri Vaidya, Dolly Joshi, Kanjaksha Ghosh, Prantar Chakrabarti, Babu Rao Vundinti,