Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4134637 | Human Pathology | 2009 | 6 Pages |
Abstract
SummaryChronic basophilic leukemia is a rare and poorly characterized entity. Only a limited number of cases have been described. Herein, we report a patient who presented with fatigue, weight loss, leukocytosis, persistent prominent basophilia, and mild eosinophilia. The bone marrow showed features characteristic of a myeloproliferative neoplasm with a marked increase in maturing basophils. The basophils exhibited nuclear hypersegmentation, abnormal granulation, and abnormally low CD38 expression. Conventional karyotyping revealed a t(5;12)(q31;p13). ETV6 but not PDGFRB rearrangement was detected by fluorescence in situ hybridization.
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Authors
Guilin Tang, Lesley J. Woods, Sa A. Wang, Doreen Brettler, Mary Andersen, Patricia M. Miron, Liberto Pechet, Bruce A. Woda, Suyang Hao,