Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4135710 | Human Pathology | 2006 | 5 Pages |
Abstract
SummaryHistopathology and special stains of a brain biopsy specimen from a 42-year-old man revealed numerous gram-positive bacilli arranged in branching filaments, suggesting Nocardia infection. Antibiotic therapy with trimethoprim-sulfamethoxazole markedly decreased the abscess size, and the patient improved. DNA was analyzed from formalin-fixed sections of the cerebral abscess by a 16S ribosomal DNA polymerase chain reaction assay demonstrating the presence of either Nocardia farcinica or N otitidiscaviarum. A species-specific polymerase chain reaction assay confirmed N farcinica as the etiologic agent.
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Authors
Kathleen M. Tatti, Wun-Ju Shieh, Sonya Phillips, Michael Augenbraun, Chandrakant Rao, Sherif R. Zaki,