HIF-3α mRNA expression changes in different tissues and their role in adaptation to intermittent hypoxia and physical exercise

► We investigated the role of HIF-3α in response to hypoxia and physical exercise. ► The HIF-3α silencing was performed by RNA interference technology. ► IHT reduced the effect of acute hypoxia on HIF-3α mRNA expression. ► The HIF-3α silencing led to the physical endurance elevation. ► The antiHIF-3α siRNA influenced on some HIF-target gene expression.