Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4137573 | Revista Española de Patología | 2013 | 4 Pages |
Abstract
Mastocytosis is a group of clonal neoplastic disorders characterized by tissue proliferation of mastocytes morphologically and/or molecularly abnormal, being systemic when it has extracutaneous location. The clinical picture is variable and nonspecific. Cases have been described associated to other hematological neoplasms, especially those of myeloid and, to a lesser extent, lymphoid type. We present two cases of systemic mastocytosis involving bone marrow, lymph nodes and skin in elderly female patients which were initially diagnosed clinically as lymphoma. However, an abnormal proliferation in cumulus of mastocytes was identificated histologically using Giemsa and confirmed by CD117, CD25 and CD45. One of the patients had a rapid, unfavorable clinical evolution.
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Authors
Idania Lubo-Julio, Ileana FermÃn-Santana, Amelia Lissia, MarÃa A. Piras, Giovannino Massarelli,