Tumores de células granulares múltiples en el tracto gastrointestinal

Granular cell tumours (GCTs) are rarely found in the gastrointestinal tract. We describe a case of a 55-year-old woman with GCTs in colon and oesophagus and a previous history of similar lesions in subcutaneous tissue, skin and breast. Endoscopic examination revealed submucosal tumours in the sigmoid and ascending colon, cecum and distal oesophagus. Endoscopic mucosal resection and biopsy followed by histological examination revealed the nodules to be composed of plump histiocyte-like cells with abundant eosinophilic, granular, PAS positive cytoplasm with small nuclei lacking nucleoli. No mitosis, pleomorphism or necrosis were observed. The immunohistochemistry revealed strong positivity for S100, CD56, neuronal specific enolase, inhibin and PGP9.5 in the tumour cells, which were negative for smooth muscle actin and p53. Ki-67 showed a very low proliferation index (1%). The morphological and immunohistochemical findings led to a diagnosis of benign GCTs. At present, endoscopic mucosal resection is recommended for the diagnosis and treatment of submucosal GCTs, as their malignant counterpart is extremely rare in gastrointestinal tract.