Astrocytic neoplasms of the central nervous system and orbit: a morphologic perspective

Astrocytic neoplasms constitute a highly diverse category of neoplasms in the central nervous system and the orbit that span from almost benign to highly malignant neoplasms. Most tumors in the former category are potentially cured by surgery alone, while the latter group of tumors do not respond to any form of current treatment. The most critical advance in our understanding of the pathology of these tumors has divided this group into circumscribed (or solid) and infiltrating (or diffuse) categories. These two categories differ from one another in virtually every aspect and their distinction has become the principle role of the pathologist in guiding appropriate management. There is increasing insight into the biology of these neoplasms but the fundamental role of the pathologist still remains the correct morphological recognition. This short review highlights the most pertinent features of neoplasms considered within this diverse family.