Easy access to quinoxaline derivatives using alumina as an effective and reusable catalyst under solvent-free conditions

Alumina as a cheap, heterogeneous and reusable catalyst can provide environmentally friendly alternatives for synthesis of quinoxaline derivatives via condensation of 1,2-diamines and 1,2-dicarbonyl compounds under solvent-free conditions. The products could be separated simply from catalyst by filtration and the catalyst could be recycled and reused for several times without noticeably decreasing in catalytic activity.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (110 K)Download as PowerPoint slideResearch highlights▶ Acidic alumina under neat conditions catalyzes condensation of 1,2-diamines and 1,2-dicarbonyl compounds. ▶ The high reusability of alumina which is easily separated from the reaction media as well as easy and safe work-up procedure providing ready scalability, makes this solvent-free strategy more attractive for practical goal.