Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4149415 | Archives de Pédiatrie | 2008 | 6 Pages |
Abstract
Ninety-four percent of subjects had a Mabs titer greater than 120 mIU/ml. Women born before 1983 had significantly higher geometric mean titers (GMTs) of Mabs than those born after 1983 (1358 mIU/ml vs. 731 mIU/ml [p < 0.001]). The comparison of the 4 cohorts showed a significant decrease (p < 0.001) in GMTs of Mab in the female population with increasing age (670, 771, 1173, and 1821 mUI/ml, respectively, in the 12-18, 19-22, 23-30, and 31-40 years age groups). For the 1st time in France, we show in women of childbearing age that in 2005-2006 neutralizing Mab GMTs were far above protective threshold for all age groups. Women in younger age groups (with high MVC) have significantly lower Mab titers. A lower passive transfer of Mab to their offsprings could result in a shorter period of measles protection and question the measles vaccine 1st dose at 1 year.
Keywords
Related Topics
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Perinatology, Pediatrics and Child Health
Authors
A. Gagneur, D. Pinquier, M. Aubert, B. Soubeyrand, L. Balu, O. Brissaud, C. Gras-Le-Guen, I. Hau-Rainsard, O. Mory, G. Picherot, L. De Pontual, J.-L. Stephan, P. Reinert,