Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4157411 | Journal of Pediatric Surgery | 2010 | 4 Pages |
Abstract
Fanconi anemia (FA) is an autosomal recessive inherited syndrome characterized by congenital abnormalities, aplastic anemia, and a high likelihood of developing cancer. We describe a child who presented with 2 synchronous solid tumors (Wilms tumor and neuroblastoma), later found to have FA, who developed severe toxicity and died after a first cycle of chemotherapy. Our experience emphasizes that a predisposing genetic condition should be sought in cases of multiple tumors and that managing FA patients with cancer can be particularly difficult.
Related Topics
Health Sciences
Medicine and Dentistry
Perinatology, Pediatrics and Child Health
Authors
Alessia Compostella, Tiziana Toffolutti, Pietro Soloni, Patrizia Dall'Igna, Modesto Carli, Gianni Bisogno,