Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4158200 | Journal of Pediatric Surgery | 2009 | 10 Pages |
Abstract
Nitrofen can interfere with lung development early in the fetal rat development before and separate from diaphragm development, and increased expression of TGF-β1 in the lung of CDH rat model may suppress lung growth and development. Prenatal treatment with Tet can improve the growth of the lung of the nitrofen-induced CDH fetuses and its mechanism seems to be involved in downregulating the expression of TGF-β1. It is a likely new approach to treat CDH and its coexistent lung hypoplasia by maternal Tet administration.
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Authors
Chang Xu, Wenying Liu, Zhongxian Chen, Yuanxiang Wang, Zhongxun Xiong, Yi Ji,