Article ID Journal Published Year Pages File Type
4158624 Journal of Pediatric Surgery 2009 5 Pages PDF
Abstract
Intestinal I/R leads to decreased ileal GSH synthesis, which could contribute to GSH depletion. Hypothermia preserves GSH synthesis during intestinal I/R injury, and this could protect from further tissue damage. We speculate that reactive species released during I/R injury impair the enzymes of GSH synthesis, whereas these enzymes are protected by moderate hypothermia.
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Related Topics
Health Sciences Medicine and Dentistry Perinatology, Pediatrics and Child Health
Preview
Glutathione synthesis in intestinal ischaemia-reperfusion injury: effects of moderate hypothermia
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