Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4160811 | Journal of Pediatric Surgery | 2006 | 6 Pages |
Abstract
Although in vitro coculture with NB does not induce significant changes in either CCR7 or CCL19 expression, profound functional impairments in CCR7/CCL19-mediated migration occurs. These findings suggest that intracellular signal transduction pathways for these chemokines may be impaired by tumor. Targeting this chemokine-receptor pathway may provide a novel therapeutic strategy.
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Authors
Sonya R. Walker, P. Dafé Ogagan, Dilhari DeAlmeida, Alexander M. Aboka, Edward M. Jr.,