Solid pseudopapillary neoplasm of the pancreas in pediatric patients: A case report and institutional case series

•Solid pseudopapillary neoplasm (SPN) of the pancreas is the most common form of pancreatic cancer in children.•Immunohistochemistry may be used to confirm the diagnosis of SPN of the pancreas.•Patients with SPN of the pancreas who undergo complete surgical resection can expect an excellent prognosis.

Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor presenting in adolescent and young adult females. A previously healthy 13 year-old female presented to our institution with abdominal pain and emesis. Imaging revealed a pancreatic cystic mass. Endoscopic ultrasound (EUS) with fine needle biopsy suggested SPN. Pathologic evaluation following resection revealed immunohistochemical (IHC) staining positive for β-catenin and α-1-antitrypsin despite extensive necrosis. We discuss this patient as well as our institutional series of SPN of the pancreas, describing the evaluation, management, and histopathology of this rare tumor.