Biometry of the hypospadic penis after hormone therapy (testosterone and estrogen): A randomized, double-blind controlled trial

Preoperative use of topical testosterone increases penile size, diameter of the penis and glans. The use of estradiol does not change penile biometry. Side effects occur mainly with the use of testosterone and are transient. No significant and persistent hormonal changes were observed.Table. Positive finding of the study.CGTGEGp-valueVariation in size in cm (median)Penile length0.00 (0.0-0.0)0.70 (0.2-1.4)0.00 (0.0-0.4)0.0005Penile diameter0.00 (0.0-0.1)0.80 (0.0-0.3)0.00 (0.0-0.0)0.0094Glans diameter0.00 (0.0-0.1)0.10 (0.0-0.4)0.00 (0.0-0.1)0.0026Side effects, n (%)Pubic hair0 (0%)24 (85%)3 (14%)<0.0001Darkening of skin0 (0%)21 (74%)12 (50%)<0.0001Median (interquartile range).