Botulinum toxin injection in the pediatric population with medically refractory neuropathic bladder

BTI is a safe and effective treatment option for pediatric patients with neuropathic bladder refractory to standard therapy. The degree of continence observed after BTI in our series was higher for AI rather than AR patients.Table. Urodynamic changes following Botulinum toxin injection.Pre-Botulinum toxin injection% of age-expected bladder capacityPost Botulinum toxin injection% of age-expected bladder capacity% improvement in urodynamic parametersP-valueCystometric capacity (ml)2276033187460.008Maximum detrusor pressure (cm H2O)6344430.002Compliance (ml/cm H2O)4.38.81040.001Uninhibited detrusor contractions (UDC)14/22 (63% of total patients)4/14 (29% of patients with UDC pre-BTI)