Article ID Journal Published Year Pages File Type
4162505 Journal of Pediatric Urology 2012 4 Pages PDF
Abstract

ObjectiveTo perform a clinicopathologic study with follow-up on this rare subset of tumors in the pediatric population.Patients and methodsA search was made through the surgical pathology files of two academic institutions for cases of non-translocation associated renal cell carcinoma in patients younger than 20 years old from 1995 to 2011.Results12 cases were identified from 350 pediatric patients with renal tumors (prevalence = 3.4%). The mean age at diagnosis was 11 years (range 1–18 years). The average tumor size was 7.3 cm (range 3.0–15.0 cm). Pathological staging analysis revealed 7/12 (58%) pT1 tumors, 3/12 (25%) pT2 tumors, and 2/12 (17%) pT3 tumors. Lymph node metastasis was present in 3/12 (25%) patients. The majority of tumors 9/12 (75%) were Fuhrman nuclear grade 2, while 3/12 (25%) cases were Fuhrman nuclear grade 3. Tumor necrosis was identified in 5/12 (42%) tumors, and angiolymphatic invasion was identified in 4/12 (33%) tumors; 1 patient developed lung metastasis.ConclusionsPathologic parameters typically associated with poor outcome in adults, including metastasis/high tumor stage, high Fuhrman nuclear grade, angiolymphatic invasion, and tumor necrosis, did not lead to death in any of the patients in our series.

Related Topics
Health Sciences Medicine and Dentistry Perinatology, Pediatrics and Child Health
Authors
, , , , , ,