| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4164152 | Journal of Pediatric Urology | 2008 | 5 Pages |
ObjectiveTo estimate dietary protein intake in children with idiopathic hypercalciuria (HC) and/or hyperuricosuria (HU).Patients and methodsWe compared the 24-h urinary excretion of urea, as a reflection of protein intake, in four age- and sex-matched groups, each comprising 56 consecutive children: (1) HC, (2) HU, (3) HC + HU and (4) control.ResultsUrinary urea excretion was significantly higher in HC, HU and HC + HU than in controls. HC and HU children had similar urea excretion. HC + HU children had urinary urea significantly higher than HC and HU, but urinary calcium similar to HC and urinary uric acid excretion similar to HU subjects. Urinary calcium was significantly (R2 = 0.21) correlated with urea excretion in HC children only, whereas urinary uric acid was significantly (R2 = 0.21) correlated with urinary urea in HU children only. No significant correlation between urinary urea and calcium or uric acid excretion was found in HC + HU patients although they had the highest urinary urea. A significant (p = 0.004) interaction between urinary urea and sodium in increasing urinary calcium excretion resulted only in the HC group.ConclusionThe association of dietary protein excess with HC and/or HU is conditioned by an individual (genetic?) predisposition and may be produced by different mechanisms.
