Article ID Journal Published Year Pages File Type
4164718 The Journal of Pediatrics 2015 11 Pages PDF
Abstract
Prostaglandins and nitric oxide are the most important vasodilators opposing DA closure. Indomethacin inhibits prostaglandin production, but not nitric oxide production. Because decreased SLCO2A1 and NOS3 expression can lead to increased prostaglandin and decreased nitric oxide concentrations, we speculate that prostaglandin-mediated vasodilation may play a more dominant role in maintaining the “non-Caucasian” patent DA, making it more likely to close when inhibited by indomethacin.
Related Topics
Health Sciences Medicine and Dentistry Perinatology, Pediatrics and Child Health
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