Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4164718 | The Journal of Pediatrics | 2015 | 11 Pages |
Abstract
Prostaglandins and nitric oxide are the most important vasodilators opposing DA closure. Indomethacin inhibits prostaglandin production, but not nitric oxide production. Because decreased SLCO2A1 and NOS3 expression can lead to increased prostaglandin and decreased nitric oxide concentrations, we speculate that prostaglandin-mediated vasodilation may play a more dominant role in maintaining the “non-Caucasian” patent DA, making it more likely to close when inhibited by indomethacin.
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Authors
Nahid PhD, Anne Marie MS, John M. MD, PhD, Allison BS, Chengshi PhD, Nancy K. PhD, Elaine L. PhD, Jeff MD, Ronald I. MD,