Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4165430 | The Journal of Pediatrics | 2013 | 5 Pages |
Abstract
A small fraction of cases of juvenile myelomonocytic leukemia (JMML) develop massive disease activation. Through genomic analysis of JMML, which developed in an individual with mosaicism for oncogenic KRAS mutation with rapid progression, we identified acquired uniparental disomy at 12p. We demonstrated that duplication of oncogenic KRAS is associated with rapid JMML progression.
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Authors
Motohiro MD, PhD, Naoko MD, Masafumi MD, Hiroshi MD, Aiko MS, Daisuke MD, PhD, Nobutaka MD, PhD, Ryoji MD, Seishi MD, PhD, Atsushi MD, PhD, Junko MD, PhD, Katsuyoshi MD,