Neutrophil Gelatinase-Associated Lipocalin Concentrations Predict Development of Acute Kidney Injury in Neonates and Children after Cardiopulmonary Bypass

Article ID	Journal	Published Year	Pages	File Type
4166575	The Journal of Pediatrics	2011	8 Pages	PDF

Abstract

Plasma and urine NGAL thresholds are early predictive biomarkers for AKI and its clinical outcomes after CPB. In neonates, we recommend a 2-hour plasma NGAL threshold of 100 ng/mL and 2-hour urine NGAL threshold of 185 ng/mL for diagnosis of AKI. In non-neonates, recommended AKI thresholds are 50 ng/mL for both 2-hour plasma and urine NGAL.

Keywords

AKI CPB ROC EGFR NGAL RACHS-1 AUC acute kidney injury cardiopulmonary bypass Estimated creatinine clearance Acute Kidney Injury Network neutrophil gelatinase-associated lipocalin Areas under the curve estimated glomerular filtration rate AKIN serum creatinine receiver-operating characteristic SCR