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Interpretation of Biomarkers of Bone Metabolism in Children: Impact of Growth Velocity and Body Size in Healthy Children and Chronic Disease

Article ID Journal Published Year Pages File Type
4166613 The Journal of Pediatrics 2008 9 Pages PDF
Abstract
These data illustrate the potential confounding effects of growth and WB-BMC on bone metabolism biomarkers in children. After adjustment for these effects, Crohn's disease was associated with lower biomarkers of bone formation and greater bone resorption.
Keywords
DPDRANKLIL-1βOPGDXAPCDAIBSAPNFκBbone-specific alkaline phosphataseOsteoprotegerinInterleukin-1βtumor necrosis factor-αdual energy X-ray absorptiometrybody mass indexBMIPediatric Crohn's Disease Activity IndexCoefficient of VariationTNF-αnuclear factor κB
Related Topics
Health Sciences Medicine and Dentistry Perinatology, Pediatrics and Child Health
Preview
Interpretation of Biomarkers of Bone Metabolism in Children: Impact of Growth Velocity and Body Size in Healthy Children and Chronic Disease
Authors
Shamir MD, MPH, Meena MD, Justine PhD, Babette S. PhD, Jon M. MD, MSCE, Mary B. MD, MSCE,
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The Journal of Pediatrics
Journal: The Journal of Pediatrics
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DPD
RANKL
IL-1β
OPG
DXA
PCDAI
BSAP
NFκB
bone-specific alkaline phosphatase
Osteoprotegerin
Interleukin-1β
tumor necrosis factor-α
dual energy X-ray absorptiometry
body mass index
BMI
Pediatric Crohn's Disease Activity Index
Coefficient of Variation
TNF-α
nuclear factor κB
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