| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4166935 | The Journal of Pediatrics | 2009 | 5 Pages |
Abstract
We identified somatic activating thyrotropin-receptor gene mutations within autonomous thyroid nodules (ATN) in 2 girls with 1 ATN and in 1 girl with 3 ATN. A fourth patient had a somatic activating gene mutation of the alpha-subunit of the stimulating G-protein in 2 ATN. Activating somatic mutations in ATN can cause non-autoimmune hyperthyroidism in children.
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Authors
Karl Otfried MD, Nicole PhD, Natascha MD, Martin MD, Jochen MD, Thomas MD, Joachim MD,