Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4168923 | The Journal of Pediatrics | 2007 | 5 Pages |
Abstract
Immunohistology of lymphoreticular tissues of a fatal case of organic cation transporter 2 deficiency revealed inhibited proliferation with increased apoptosis in the germinal centers, resulting in “burned out” follicles. This is indicative of impaired antigen driven B cell affinity maturation. Defective humoral immune response might explain the recurrent infections in untreated organic cation transporter 2 deficiency.
Keywords
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Authors
Katalin MD, Viktória MD, Judit MSc, Norbert MD, László MD, PhD, Raffaella PhD, DSc, Paola MC, Menotti MD, Béla MD, PhD, DSc,