Neutrophil dysfunction in children

Neutrophils are important leukocytes for host protection against bacterial and fungal pathogens. Neutrophil disorders can result from reduced numbers or function and the latter are the subject of this review. Defects of neutrophil function are rare but clinically important as they can result in severe and life-threatening disease. Chronic Granulomatous Disease and Leukocyte Adhesion Defect are the most common intrinsic neutrophil defects and are focused on here with a brief description of other functional defects. Practical guidelines for investigation and management are discussed.