Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4178134 | Biological Psychiatry | 2013 | 12 Pages |
Abstract
Our data indicate that repeated cocaine exposure during early adolescence can elicit a state of mPFC disinhibition resulting from a functional impairment of the local prefrontal GABAergic network that endures through adulthood. A lack of acquisition of prefrontal GABAergic function during adolescence could trigger long-term deficits in the mPFC that may increase the susceptibility for the onset of substance abuse and related psychiatric disorders.
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Authors
Daryn K. Cass, Daniel R. Thomases, Adriana Caballero, Kuei Y. Tseng,