Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4181446 | L'Encéphale | 2016 | 7 Pages |
Abstract
The effect of stress on brain pathways could participate to the mechanisms underlying the onset of psychotic symptoms, both as a precipitating factor and as a marker of a predisposing vulnerability. This dysregulation fits into the gene x environment model: in subjects with genetic predispositions, stressful environmental factors can modify biological pathways implicated in psychiatric disorders, promoting the emergence of symptoms. However, many confounding factors obscure the literature, and further studies are needed in schizophrenic patients, UHR and FEP patients to clarify the precise role of stress in psychotic transition. Identification of stress biomarkers could help diagnosis and prognosis, and pave the way for specific care strategies based on stress-targeted therapies.
Related Topics
Health Sciences
Medicine and Dentistry
Psychiatry and Mental Health
Authors
B. Chaumette, O. Kebir, C. Mam Lam Fook, J. Bourgin, B.P. Godsil, R. Gaillard, T.M. Jay, M.-O. Krebs,