| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4182941 | L'Encéphale | 2009 | 7 Pages |
Abstract
The results are consistent with the physiopathological hypothesis of an induction of IDO underlying depressive and anxiety symptoms related to IFN-alpha therapy in patients with chronic active hepatitis C. Nevertheless, this pilot study allows no firm conclusion since sample effective is weak and delay between IFN-alpha weekly injection and psychiatric and biological assessment was not controlled and thus may have biased our findings. However, these encouraging results advocate for further exploration of tryptophan metabolism for a better understanding of individual vulnerability to IFN-alpha-induced psychiatric adverse effects.
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Authors
J. Vignau, O. Costisella, V. Canva, M. Imbenotte, A. Duhamel, M. Lhermitte,