Anger- and aggression-related traits are associated with polymorphisms in the 5-HT-2A gene

BackgroundThis study investigates the association of four single nucleotide polymorphisms (SNPs) in the serotonin 2A (5-HT-2A) receptor gene with anger-, aggression- and suicide-related behavior in a total of 566 subjects (203 German suicide attempters and 363 German community-based healthy volunteers).MethodsAnger- and aggression-related traits were assessed by using the State Trait Anger Expression Inventory (STAXI) and the Questionnaire for Measuring Factors of Aggression (FAF).ResultsThree (rs643627–rs594242–rs6311: A–C–T), two (rs594242–rs6311: C–T) and a single functional (rs6311: T) marker were protective against suicidal behavior. The complementary makers (rs594242–rs6311: G–C and rs6311: C) were associated with increased risk for non-violent (p = 0.01; p = 0.009 respectively) and impulsive suicidal behavior (p = 0.03; p = 0.01 respectively). Furthermore, CC-homozygotes for the functional SNP rs6311 reported more anger- (p = 0.004) and aggression-related behavior (p = 0.011).ConclusionWe conclude that variations in the 5-HT-2A gene may modify the phenotype of suicide-, anger-, and aggression-related behavior. Further studies should especially focus on intermediate personality traits in this context.