| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4188810 | Psiquiatría Biológica | 2008 | 13 Pages |
Abstract
Study of neurotransmission targets for antidepressants seems to be the most effective approach for the design of new antidepressant drugs. In this context, the α2-adrenoceptors play a major role in the mechanism of action of these agents. In addition, antidepressants, whether with a noradrenergic or a serotonergic profile, are able to modulate the noradrenergic system, demonstrating that both systems are modulated at the same time in the central nervous system.
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Authors
Jorge Emilio Ortega, Luis Felipe Callado, José Javier Meana,