Is performing lobectomy after the use of bevacizumab for a lung tumor dangerous?

•A safety of major lung resection after the use of Bev remains controversial.•Is it really dangerous to perform major lung resection after the use of Bev for a lung tumor?•Our results provide reliable information regarding the operative safety.

Recent new drugs, such as bevacizumab (Bev), also result in a remarkable response. However, the safety of major lung resection after the use of Bev remains controversial. Is it really dangerous to perform major lung resection after the use of Bev for a lung tumor? In this report, we describe two patients who underwent surgery safely without fragile pathological findings of the vessels.