Disease Progression Patterns of SHIV-KB9 in Rhesus Macaques of Chinese Origin in Comparison with Indian Macaques

ObjectiveTo develop a model of SHIV-KB9/Chinese origin rhesus (Ch Rh) macaques for vaccine research and to compare the pathogenesis of shiv-kb9 in Ch Rh macaques with that reported in Indian rhesus (Ind Rh) macaques.MethodsSeven mamu-A*01 negative Ch Rh macaques were inoculated intravenously with 1-10000 mid50 of shiv-kb9. The monkeys were monitored for viral load, cd4, cd8, SHIV-specific antibody and virus genetic variation. The results were compared with those previously observed in Ind Rh macaques.ResultsAs compared to that observed in Ind Rh macaques, shiv-kb9 in Ch Rh macaques displayed three identical disease progression patterns. However, the primary pattern was not identical between the two subspecies. The level of plasma viremia differed in SHIV-KB9-infected Ch Rh macaques which exhibited different outcomes from those in Ind Rh macaques. Generally, the values of viral load and the maintenance of cd4+ t cells were associated with humoral responses. Otherwise, the viral genetic distances (divergence, diversity) were larger in animals (m419, m425) with their cd4+ t cells profoundly depleted.ConclusionThe model of SHIV-KB9/Ch Rh macaques displays a relatively slow progression to aids compared with Ind Rh macaques, which may more accurately reflect the potential of candidate vaccines in humans.