Correlation between the transdermal characteristics of pseudoephedrine and amygdalin in majiepingchuan in vitro

ObjectiveTo analyze the transdermal profile of pseudoephedrine and amygdalin in the Traditional Chinese Medicine majiepingchuan in rat skin and to reveal their interaction.MethodsA Franz diffusion cell was used in vitro to evaluate the transdermal parameters of cumulative transdermal flux (Qtot), cumulative transmission (Ttot), and mean penetration rate (Kp) of pseudoephedrine and amygdalin in majiepingchuan. Linear regression analyses of Qtot over time of pseudoephedrine vs amygdalin and their ratios was adopted for correlation evaluation.ResultsAt 1,2,4,6, and 8 h, the Qtot, Ttot and Kp of pseudoephedrine showed a good correlation with that of amygdalin.ConclusionThere was a small difference in the ratios of Qtot, Ttot and Kp between pseudoephedrine and amygdalin, and a correlation between them.