Genome wide expression analysis of the effect of Socheongryong Tang in asthma model of mice

ObjectiveTo investigate the molecular effect of Socheongryong Tang (SCRT, Xiaoqinglong Tang in Chinese) on whole genome level in asthma mouse model by microarray technology.MethodsAsthma was induced by intranasal instillation of ovalbumin in mouse. After administration of SCRT on asthma-induced mouse, the expression of genes in lung tissue was measured using whole genome microarray. The functional implication of differentially expressed genes was performed using ontological analysis and the similarity of promoter structure of genes was also analyzed.ResultsTreatment of SCRT restored expression level of many up- or down-regulated genes in asthma model, and this recovery rate means SCRT could regulate a set of genes having specific TFBS binding sites.ConclusionIn this study, we identified a set of genes subjected to similar regulation by SCRT in asthma model in mice.