Effect of Shenqi Compound Formula on PPARγ in White Adipose Tissue of Rats with Macrovascular Lesion in Early Stage of Diabetes

ObjectiveTo investigate the effect of Shenqi Compound Formula (SCF) on peroxisome proliferators-activated receptor γ (PPARγ) in white adipose tissue of rats with macrovascular lesion in early stage of diabetes.MethodsCorresponding treatment was given to rats in model group, Ramipril group, normal control group, low dosage SCR group and high dosage SCR group respectively for 32 days. The expressions of PPARγ and adiponectin Messenger RNA (mRNA) were detected by real-time reverse transcriptase polymerase chain reaction.ResultsThe expressions of PPARγ and adiponectin mRNA increased significantly in both low and high dosage SCF groups as compared with the model group, and a positive linear correlation was found between the expressions of PPARγ and adiponectin mRNA.ConclusionsSCF can prevent macrovascular lesion in early stage of diabetes, which is possibly related with up-regulating expressions of PPARγ and activating PPARγ.