Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4204352 | Archivos de Bronconeumología | 2010 | 7 Pages |
Abstract
Pulmonary fibrosis in CdCl2 rats was characterized by a marked decrease in pulmonary function with respect to healthy controls -reductions of 28% in IC, 38% in CL, 31% in FVC, and 54% in FEF75%- which was partially recovered after LGF injection -18% IC, 27% CL, 19% FVC and 35% FEF75%-; increase in collagen and elastin contents -165% and 76%, respectively, in CdCl2 rats, versus 110% and 34% after LGF injection-; and increases in AIA and LM, partially reverted by LGF. Conclusions: Together, these data seem to demonstrate that LGF is able to improve lung function and partially reverts the increase in lung matrix proteins produced by CdCl2 instillation.
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Authors
Lourdes MartÃnez-Galán, Laura del Puerto-Nevado, Sandra Pérez-Rial, Juan José DÃaz-Gil, Nicolás González-Mangado, Germán Peces-Barba,