Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4207695 | Clinics in Chest Medicine | 2008 | 6 Pages |
Abstract
Cellular dysfunction is a commonplace sequelum of sepsis and other systemic inflammatory conditions. Impaired energy production (related to mitochondrial inhibition, damage, and reduced protein turnover) appears to be a core mechanism underlying the development of organ dysfunction. The reduction in energy availability appears to trigger a metabolic shutdown that impairs normal functioning of the cell. This may well represent an adaptive mechanism analogous to hibernation that prevents a massive degree of cell death and thus enables eventual recovery in survivors.
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Authors
Mervyn Singer,