Impaired lung diffusing capacity for nitric oxide and alveolar-capillary membrane conductance results in oxygen desaturation during exercise in patients with cystic fibrosis

BackgroundExercise has been shown to be beneficial for patients with cystic fibrosis (CF), but for some CF patients there is a risk of desaturation, although the predicting factors are not conclusive or reliable. We sought to determine the relationship between the diffusion capacity of the lungs for nitric oxide and carbon monoxide (DLNO and DLCO) and the components of DLCO: alveolar-capillary membrane conductance (DM), and pulmonary capillary blood volume (VC) on peripheral oxygen saturation (SaO2) at rest and during exercise in CF.Methods17 mild/moderate CF patients and 17 healthy subjects were recruited (age = 26 ± 7 vs. 23 ± 8 years, ht = 169 ± 8 vs. 166 ± 8 cm, wt = 65 ± 9 vs. 59 ± 8 kg, BMI = 23 ± 3 vs. 22 ± 3 kg/m2, VO2PEAK = 101 ± 36 vs. 55 ± 25 % pred., FEV1 = 92 ± 22 vs. 68 ± 25 % pred., for healthy and CF, respectively, mean ± SD, VO2PEAK and FEV1 p<0.001). Subjects performed incremental cycle ergometry to exhaustion with continuous monitoring of SaO2 and measures of DLNO, DLCO, DM and VC at each stage.ResultsCF patients had a lower SaO2 at rest and peak exercise (rest = 98 ± 1 vs. 96 ± 1%, peak = 97 ± 2 vs. 93 ± 5%, for healthy and CF, respectively, p < 0.01). At rest, DLNO, DLCO, DM were significantly lower in the CF group (p < 0.01). The difference between groups was augmented with exercise (DLNO = 117 ± 4 vs. 73 ± 3 ml/min/mmHg; DLCO = 34 ± 8 vs. 23 ± 8 ml/min/mmHg; DM = 50 ± 1 vs. 34 ± 1, p < 0.001, for healthy and CF respectively). Peak SaO2 was related to resting DLNO in CF patients (r = 0.65, p = 0.003).ConclusionsThese results suggest a limitation in exercise-mediated increases in membrane conductance in CF which may contribute to a drop in SaO2 and that resting DLNO can account for a large portion of the variability in SaO2.