| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4208765 | Journal of Cystic Fibrosis | 2011 | 7 Pages |
BackgroundAdult patients with cystic fibrosis (CF) have resting abnormal large artery haemodynamics. Here, we obtain further insight in patients with CF by evaluating haemodynamic response to physiological stress.MethodsThirty-six stable CF patients mean (SD) age 28.9 (9.0) years and 25 controls matched for age, gender and body mass index were studied. Central haemodynamic parameters; including augmentation index (AIx) and wasted left ventricular pressure energy (∆EW) were determined pre, during and post light intensity cycle ergometry.ResultsDuring exercise, despite a similar heart rate and blood pressure, patients had comparatively greater ∆EW (P = 0.03) and trend towards greater AIx (P = 0.07) than controls. Exercise ∆EW was greatest in patients with CF related diabetes (n = 11). In all subjects, exercise ∆EW was related to age (r = 0.54, P < 0.001) and FEV1% predicted (r = − 0.32, P = 0.01).ConclusionsAdults with CF have an abnormal haemodynamic response to exercise. This finding has deleterious implications for myocardial performance.
