Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4212141 | Respiratory Medicine | 2006 | 6 Pages |
Abstract
SummaryRecombinant interferon-α (rINF-α) is an immunomodulator used in the treatment of various conditions, including viral infections and malignancies. The use of rINF-α has been associated with the development of sarcoidosis in recent case reports. In this series, we report the incidence of sarcoidosis in recipients of rINF-α for hepatitis C viral (HCV) infection at our institution. We also review the 57 additional cases of sarcoidosis associated with rINF-α described in the literature, including clinical presentation, radiographic findings, management, and outcomes, and discuss the potential mechanisms by which rINF-α may lead to the development of sarcoidosis.
Keywords
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Authors
Hilary J. Goldberg, Douglas Fiedler, Amy Webb, Jashiree Jagirdar, Anastacio M. Hoyumpa, Jay Peters,