Successful therapy with high-dose steroids and cyclosporin in lenograstim-induced acute respiratory distress syndrome

SummaryA 59-year-old man was admitted to a dental clinic complaining of toothache and high fever in May 2007. Laboratory studies demonstrated pancytopenia and severe inflammatory findings. Therefore, he was admitted to our hospital. The patient was diagnosed with acute myeloid leukemia with multilineage dysplasia and severe pulpitis. After treatment with antibiotics and lenograstim was initiated, acute respiratory distress syndrome (ARDS) was induced. This is, to our knowledge, the first case of lenograstim-induced ARDS, resistant to corticosteroids alone, which was successfully treated with both corticosteroids and cyclosporin.