Three-Dimensional Isotropic Wavelets for Post-Acquisitional Extraction of Latent Images of Atherosclerotic Plaque Components from Micro-Computed Tomography of Human Coronary Arteries

Isotropic wavelet analysis permits high resolution, multi-dimensional identification of coronary atherosclerotic plaque components in micro-CT with sensitivity and specificity similar to that achieved with data obtained invasively (from IVUS in vivo) using one-dimensional wavelets. Further studies are necessary to test the applicability of this technology to clinical, multi-detector scanners.