Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4221386 | Clinical Imaging | 2015 | 4 Pages |
Abstract
Kaposiform hemangioendothelioma (KHE) is a vascular tumor with poor prognosis. We present a child with progressive disability, extreme pain, and autonomic dysfunction due to a retroperitoneal KHE where radiologic characteristics were essential for diagnosis and monitoring of response to therapy. He received sirolimus, and the symptomatology resolved completely. Repeat MRIs revealed fast marked decrease in vascularity of the tumor, although the volume was not significantly affected. We suggest that the sirolimus-induced tumor de-vascularization may explain the clinical and coagulopathy improvement.
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Authors
Ionela Iacobas, Mitchell L. Simon, Tali Amir, Christopher E. Gribbin, Thomas G. McPartland, Matthew R. Kaufman, Stanley Calderwood, John L. Nosher,