Hepatocellular adenoma showing high uptake of 18F-fluorodeoxyglucose (FDG) via an increased expression of glucose transporter 2 (GLUT-2)

Hepatocellular adenoma (HCA) is a benign liver neoplasm composed of hepatocytes. We experienced HCA demonstrating a high uptake of 18F-fluorodeoxyglucose (FDG) on positron emission tomography–computed tomography, mimicking a malignant tumor. The mechanism underlying the uptake of FDG has not been identified. Here, we discuss that an enhancement of glucose metabolism via an increased expression of glucose transporter 2 may have a role in the high uptake of FDG shown by HCAs.