Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4224202 | The Egyptian Journal of Radiology and Nuclear Medicine | 2015 | 7 Pages |
PurposeThe purpose of this study was to evaluate the usefulness of apparent diffusion coefficient (ADC value) in differentiating between probably benign breast lesions and, suspicious lesions (ACR-BIRADS categories 3 and 4 respectively).Patients and methodsBreast lesions meeting study criteria were identified on dynamic contrast enhanced (DCE)-MRI examinations in 48 women over the course of the study period for 2 years. We found 27 (56.2%) of the cases probably benign as their BIRADS category 3 and the remaining 21 (43.7%) cases were category 4. Images were obtained with diffusion sensitizing gradients of 0 and 750 mm2/s. The apparent diffusion coefficient (ADC) was calculated and correlated with the histological data.ResultsThe ADC values recorded a sensitivity of 97.9% and a specificity of 80%. The positive predictive value was 95.7% in differentiation between the benign and suspicious breast lesions. The difference in mean ADC for benign breast lesions (BIRADS-3, 1.45 ± 0.46 × 10−3 mm2/s), and suspicious lesions (BIRADS-4, 1.06 ± 0.56 × 10−3 mm2/s) was statistically significant.ConclusionIncluding the ADC diffusion coefficient in the diagnostic work up of patients with indeterminate breast lesions can help in the differentiation between benign and malignant breast lesions.