Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4227076 | European Journal of Radiology | 2009 | 10 Pages |
ObjectivesDifferent techniques for measuring of perfusion are clinically available, but these are usually applied to healthy brain tissue.Material and methodsFive different techniques were used here in 12 patients with brain tumors to investigate the impact of tumor vascularization on the perfusion signal: three qualitative dynamic contrast-enhanced/susceptibility-contrast magnetic resonance imaging (DCE-MRI/DSC-MRI) techniques exploiting T1, T2, T2* contrast, and two quantitative techniques, pulsed arterial spin labeling (PASL) and H215O positron emission tomography (H215O-PET).ResultsIn a first approximation, a linear correlation was found between all five imaging modalities regarding the perfusion signal of both, normal brain tissue and tumor. The estimated values for tumor perfusion differed significantly between the techniques (1 = methodical mean in arbitrary units): PASL: 0.83, H215O-PET: 0.62, T1-DCE: 1.73, T2-DCE: 0.69, T2*-DSC: 0.89.ConclusionsThe tumor perfusion values, determined with different techniques are not comparable. The T2*-DSC, here applied with contrast agent presaturation of extravascular space, and PASL depict median perfusion most reliably.